COMPANY MILESTONES
| 1974 | Sangi Co., Ltd. established in Tokyo |
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| 1978 | Subsidiary Dental Kagaku Co., Ltd. established to produce hydroxyapatite First laboratory facility, Tochigi Prefecture |
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| 1980 | Second R&D laboratory, Saitama Prefecture World’s first hydroxyapatite remineralizing toothpaste ”APADENT” launched |
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| 1985 | Subsidiary Apatite Co., Ltd. established to handle sales Success of anticaries field trials among Japanese schoolchildren Second toothpaste brand ”APAGARD” launched |
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| 1993 | Sangi’s proprietary hydroxyapatite approved as an active anticaries ingredient, “Medical Hydroxyapatite,” by the Japanese government |
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| 1995 | Sangi and its two subsidiaries merged Blockbuster TV commercial series boosts sales of APAGARD, which briefly captures 20% market share |
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| 1996 | Relocation and expansion of Saitama R&D laboratory |
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| 2003 | Medical Hydroxyapatite reduced to 2-figure nanoparticle size, enhancing remineralization and restorative whitening capability |
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| 2004 | “RENAMEL” brand launched exclusively for the dental route |
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| 2005 | Sangi awarded a 2-year grant from Japan's New Energy and Industrial Technology Development Organization (NEDO) for its hydroxyapatite catalyst development (ethanol to butanol) |
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| 2007 | Sangi's 70th hydroxyapatite-related patent registered |
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| 2009 | ISO 9001:2000 certification Sangi Online Shop opened |
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| 2010 | Sangi receives a 4-year grant from the Japan Science and Technology Agency (JST) for its powder jet deposition project, a next-generation hydroxyapatite-based dental therapy system under development with Tohoku University |
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| 2011 | Commencement of toothpaste exports to Russia (APADENT) (later also APAGARD) |
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| 2013 | Commencement of toothpaste exports to Canada (OEM brand) |
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| 2014 | Company 40th anniversary celebrations Apagard’s 20th successive year as top-selling brand in Japan’s high-end “beauty whitening” toothpaste market segment |
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| 2015 | ISO 13485 certification Commencement of toothpaste exports to Singapore and China (APAGARD, APADENT) APAGARD PREMIO awarded the inaugural No.1 Dental Product ranking by Japan's top consumer product-ranking site @cosme |
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